4-Aminophenylboronic acid pinacol ester Basic information
Product Name: | 4-Aminophenylboronic acid pinacol ester |
Synonyms: | 2-(4-AMINOPHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE;4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ANILINE;4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-Y)ANILINE;4-AMINOPHENYLBORONIC ACID PINACOLATE;4-AMINOPHENYLBORONIC ACID PINACOL CYCLIC ESTER;4-AMINOPHENYLBORONIC ACID PINACOL ESTER;(4-AMINOPHENYL)BORONIC ACID, PINACOL ESTER, HCL;(4-AMINOPHENYL)BORONIC ACID PINACOL ESTER HYDROCHLORIDE |
CAS: | 214360-73-3 |
MF: | C12H18BNO2 |
MW: | 219.09 |
EINECS: | 1308068-626-2 |
Product Categories: | Boron compounds;Substituted Boronic Acids;Boronic Acid;B (Classes of Boron Compounds);Boronic Acids Esters;CHIRAL CHEMICALS;organic or inorganic borate |
Mol File: | 214360-73-3.mol |
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4-Aminophenylboronic acid pinacol ester Chemical Properties
Melting point | 165-169 °C(lit.) |
storage temp. | Refrigerator (+4°C) |
form | Crystalline Powder |
color | Almost white to light beige |
Appearance: | almost white to light beige crystalline powder |
Density: | 1.05g/cm3 |
Boiling Point: | 340ºC at 760mmHg |
Flash Point: | 159.4ºC |
Refractive Index: | 1.516 |
Water Solubility: | Insoluble |
Storage Condition: | Refrigerator (+4ºC) |
Vapor Pressure: | 8.87E-05mmHg at 25°C |
Water Solubility | Insoluble |
CAS DataBase Reference | 214360-73-3(CAS DataBase Reference) |
Safety Information
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36-37/39 |
WGK Germany | 3 |
Hazard Note | Irritant |
HazardClass | IRRITANT |
hazard declaration: | H315; H319; H335 |
waring notice: | P261; P305 + P351 + P338 |
HS Code: | 2931900090 |
4-Aminophenylboronic acid pinacol ester Usage And Synthesis
Chemical Properties | almost white to light beige crystalline powder |
Description | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylamine is a building block that has been used in the preparation of benzothiazolyl actimide fused quinazoline derivatives with antimycobaterial and anticancer activity. |
Uses | suzuki reaction |
Intermediate as | 1197160-78-3 Gedatolisib (PF-05212384, PKI-587), 796967-16-3 Linifanib (ABT-869),1173204-81-3 PKI-402, 1062169-56-5 WYE-354, 1144068-46-1 WYE-125132 (WYE-132),959122-11-3 A 922500, 885692-52-4 JNJ-28312141
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Synthesis route |
Reference:Journal of Organic Chemistry, , vol. 79, # 5 p. 1979 - 1988
Reference:Synlett, , # 8 p. 1204 - 1206
Reference:European Journal of Organic Chemistry, , # 28 p. 6263 - 6266 |
4-Aminophenylboronic acid pinacol ester Preparation Products And Raw materials
Raw materials | Triethylamine-->1,4-Dioxane-->Palladium diacetate-->4-Bromoaniline-->(OXYDI-2,1-PHENYLENE)BIS(DIPHENYLPHOSPHINE)-->Pinacolborane |
Upstream information
2,6-dichloro-9-propan-2-ylpurine; Triisopropyl Borate; Ethanol; 4-Nitroaniline; t-Butoxycarbonylglycine; 4-Iodoaniline; acetyl chloride; 2,2,2-trifluoro-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-Aminophenylboronic acid pinacol ester; 3,5-Dichloro-4-Pyridinecarbonitrile;
Downtream information
4-(4-aminophenyl)benzoic acid; 4-pyridin-2-ylaniline; (1R,2R)-2-[4-[4-(phenylcarbamoylamino)phenyl]benzoyl]cyclopentane-1-carboxylic acid; 2-(4-Aminophenyl)-6-methylbenzothiazole; Boric acid, pinacol ester; 3-(4-aminophenyl)imidazo[1,2-a]pyrazin-8-amine; tert-butyl 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate; 3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine; 4-Aminophenylboronic acid pinacol ester; (4-aminophenyl)boronic acid
