ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Basic information
Product Name: | ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE |
Synonyms: | ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-chloro-pyrimidine-5-carboxylic acid ethyl ester;2-Chloro-5-(ethoxycarbonyl)pyrimidine;5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester;PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester;2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine;Ethyl 2-Chlorpyrimidine-5-carboxylate |
CAS: | 89793-12-4 |
MF: | C7H7ClN2O2 |
MW: | 186.59568 |
EINECS: |
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Product Categories: | Heterocycle-Pyrimidine series |
Mol File: | 89793-12-4.mol |
ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Chemical Properties
Melting point | 52-60ºC |
Density: | 1.312g/cm3 |
Boiling Point: | 314.189ºC at 760 mmHg |
Flash Point: | 143.816ºC |
Refractive Index: | 1.527 |
form | Solid |
Safety Information
Risk Statements | 20/21/22 |
Safety Statements | 36/37 |
HazardClass | IRRITANT |
HS Code | 29339900 |
ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Usage And Synthesis
Chemical Properties | White to light yellow liquid |
Uses | Ethyl 2-Chlorpyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers. |
Intermediate as | 1316214-52-4 Rocilinostat (ACY-1215), 875320-31-3 Quisinostat (JNJ-26481585) 2HCl |
Synthesis route | Reference:CURIS, INC. Patent: WO2009/36016 A1, 2009 ; Location in patent: Page/Page column 69 Reference:
Reference:Journal of the American Chemical Society, ,vol. 64, p. 794,797 |
ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials | Etanol-->Hydrochloric acid-->Acetic acid glacial-->Sodium-->N,N-Dimethylformamide-->Toluene-->Phosphorus oxychloride-->Bromine-->Urea-->Dimethyl sulfate-->N,N-Dimethylaniline-->Ethyl formate -->Ethyl 3-ethoxypropionate-->Ethyl potassium malonate |
Upstream information
4-Piperidinemethanol; Ethyl 3-oxopropanoate; ethyl (Z)-2-(ethoxymethyl)-3-methoxyprop-2-enoate; Ethyl 2-hydroxypyrimidine-5-carboxylate; Ethyl 2-Chloropyrimidine-5-Carboxylate; ethyl 4-chloro-2-ethylsulfanylpyrimidine-5-carboxylate; piperazine; Ethyl (2E)-2-(ethoxymethyl)-3-methoxyacrylate; (Z)-ethyl 2-(ethoxymethyl)-3-methoxyacrylate; ethyl 2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;
Downtream information
ethyl 2-piperazin-1-ylpyrimidine-5-carboxylate; 2-Chloro-5-pyrimidinecarbonyl chloride; Ethyl 2-Chloropyrimidine-5-Carboxylate; N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide; Ethyl 2-aminopyrimidine-5-carboxylate; 2-Chloro-5-pyrimidinecarboxamide; ethyl 2-[4-(hydroxymethyl)-1-piperidyl]pyrimidine-5-carboxylate; 2-chloropyrimidine-5-carbonitrile