63744-22-9 6,8-Dibromoimidazo[1,2-a]pyrazine

63744-22-9 6,8-Dibromoimidazo[1,2-a]pyrazine

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Basic information 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Chemical Properties 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Usage And Synthesis 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials Upstream information ethylamine; chloroacetaldehyde;...
Chat Now

Product Details

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Basic information

Product Name:

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE

Synonyms:

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE;6,8-Dibromoimidazol[1,2-a]pyrazine;8-dibroMoiMidazo[1;IMidazo[1,2-a]pyrazine,    6,8-dibroMo-

CAS:

63744-22-9

MF:

C6H3Br2N3

MW:

276.92

EINECS:

1592732-453-0

Product Categories:

Heterocycles    series;CHIRAL    CHEMICALS;Aromatics;Heterocycles;Intermediates & Fine    Chemicals;Pharmaceuticals

Mol File:

63744-22-9.mol

image001.gif


6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Chemical Properties

Melting point 

165.0 to 169.0 °C

Density:

2.36 g/cm3

Refractive   Index:

1.802

Water Solubility 

Slightly soluble in water.

Hs code

2933990090


6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Usage And Synthesis

Uses

6,8-Dibromoimidazo[1,2-a]pyrazine    is a imidazopyrazine derivative with uterine-relaxing, antibronchospastic,    and cardiac-stimulating properties. 6,8-Dibromoimidazo[1,2-a]pyrazine also    displays theophylline-like properties.

Intermediate as

1229208-44-9 Entospletinib    (GS-9973)
     

image003_副本.jpg

Synthesis route

image005_副本.jpg

Reference:

  1. BAYER    PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard Patent: WO2012/80236 A1, 2012; Location in patent: Page/Page column 63; WO2012/080236 A1

  2. Oncotherapy Science, Inc. Patent: US2012/59162 A1, 2012 ; Location in patent: Page/Page column 53-54 

  3. Belanger, David B.; Curran, Patrick J.; Hruza, Alan; Voigt, Johannes; Meng, Zhaoyang; Mandal, Amit K.; Siddiqui, M. Arshad; Basso, Andrea D.; Gray, Kimberly Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5170 - 5174

  4. WO2008/5457 A2, ; Page/Page column 184 ; WO 2008/005457 A2


6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials


Upstream information

ethylamine; chloroacetaldehyde; 2-bromo-1,1-diethoxyethane; Sodium thiomethoxide; METHYLAMINE; 6,8-Dibromoimidazo[1,2-a]pyrazine; 2-bromoacetaldehyde; morpholine; Bromoacetaldehyde dimethyl acetal; 3,5-dibromopyrazin-2-amine;


Downtream information

6,8-dibromo-3-chloroimidazo[1,2-a]pyrazine; 6-bromo-3-iodo-8-methylsulfanylimidazo[1,2-a]pyrazine; 3,6,8-Tribromoimidazo[1,2-a]pyrazine; 6-bromo-N-ethylimidazo[1,2-a]pyrazin-8-amine; 6-Bromo-8-(methylthio)imidazo[1,2-a]pyrazine; 4-(6-bromoimidazo[1,2-a]pyrazin-8-yl)morpholine; imidazo[1,2-a]pyrazin-8-amine; 6-methyl-8-methylsulfanylimidazo[1,2-a]pyrazine; N-methylimidazo[1,2-a]pyrazin-8-amine; 6,8-Dibromoimidazo[1,2-a]pyrazine

 

Related Product Information

6,8-Dibromoimidazo[1,2-a]pyrazine-3-carbaldehyde 3,5-Dibromo-imidazo[1,2-a]pyrazine 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE IMIDAZO[1,2-A]PYRAZINE 6-Bromoimidazo[1,2-a]pyrazine 2-(Bromomethyl)imidazole

 

Inquiry