5909-24-0 Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

5909-24-0 Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Basic information Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Chemical Properties Safety Information Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Usage And Synthesis Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Preparation...
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Product Details

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Basic information

Product Name:

Ethyl    4-chloro-2-methylthio-5-pyrimidinecarboxylate

Synonyms:

BUTTPARK 45\03-53;ETHYL    4-CHLORO-2-METHYLTHIO-5-PYRIMIDINECARBOXYLATE;ETHYL    4-CHLORO-2-METHYLTHIOPYRIMIDINE-5-CARBOXYLATE;ETHYL    4-CHLORO-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE;2-METHYLTHIO-4-CHLORO-5-ETHOXYCARBONYLPYRIMIDINE;4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid    ethyl ester;ethyl    4-chloro-2-methylthio-5-pyrimidine-carboxyl;SIEHE    AV22429

CAS:

5909-24-0

MF:

C8H9ClN2O2S

MW:

232.69

EINECS:

227-619-0

Product Categories:

Pyrimidine series;APIs & Intermediate;Pyrimidine;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building    Blocks;Heterocycle-Pyrimidine series

Mol File:

5909-24-0.mol

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Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Chemical Properties

form 

Crystalline Powder

color 

White to light yellow to beige

Appearance:

yellow white powdery crystal

Density:

1.37 g/cm3

Melting    Point:

60-63ºC

Boiling    Point:

335.7ºC at 760 mmHg

Boiling point 

132°C/0.4mmHg(lit.)

Flash    Point:

156.8ºC

Refractive   Index:

1.568

Stability:

Stable under normal temperatures    and pressures.

Storage   Condition:

Keep Cold

InChIKey

SNNHLSHDDGJVDM-UHFFFAOYSA-N

CAS DataBase Reference

5909-24-0(CAS DataBase Reference)


Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

IRRITANT, KEEP COLD

Hs code

2933599090


Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Usage And Synthesis

Chemical Properties

off white to light yellow solid

Uses

A pyrimidine derivative as    inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus    cerevisiae

Intermediate as

260415-63-2 PD173955, 449811-92-1    R1487, 449811-01-2 Pamapimod

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Synthesis route

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Reference:

DECIPHERA PHARMACEUTICALS, LLC Patent: WO2006/71940 A2, 2006 ; Location in patent: Page/Page column 354 ; WO 2006/071940 A2

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Reference:

Bioorganic and Medicinal Chemistry Letters,vol. 10, # 15 p. 1645-1648


Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Preparation Products And Raw materials

Raw materials

Etanol-->Sodium-->Thionyl chloride-->Phosphorus oxychloride-->Potassium hydroxide-->Acetic anhydride-->Benzene-->Triethyl orthoformate-->Diethyl malonate-->2-Methyl-2-thiopseudourea sulfate-->Diethyl ethoxymethylenemalonate


Upstream information

Cyclopentylamine; ethylamine; sodium hydrogencarbonate; 3-Aminobenzotrifluoride; (3-chloro-4-methoxyphenyl)methanamine; methylamine hydrochloride;methanol; carbon monoxide; Ammonium hydroxide; 4-Pyridinemethaneamine;


Downtream information

[4-(ethylamino)-2-methylsulfanylpyrimidin-5-yl]methanol; 4-anilino-2-methylsulfanylpyrimidine-5-carbaldehyde; Ethyl 2-aminopyrimidine-5-carboxylate; (4-chloro-2-methylsulfanylpyrimidin-5-yl)methanol; 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one; ethyl 4-anilino-2-methylsulfanylpyrimidine-5-carboxylate; Diethyl 2-(Methylthio)-4,5-pyrimidinedicarboxylate; 3-bromo-6-methylsulfanyl-2H-pyrazolo[3,4-d]pyrimidine; 4-(benzylamino)-2-methylsulfanylpyrimidine-5-carboxamide; ethyl 4-(dimethylamino)-2-methylsulfanylpyrimidine-5-carboxylate


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