571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic Acid Tert-butyl Ester

571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic Acid Tert-butyl Ester

571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester Basic information 571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties 571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester Usage And...
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Product Details

571188-59-5   4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester Basic   information

Product Name:

571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester

Synonyms:

1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB 1207229;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester;tert-butyl 4-(6-aMinopyri;4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic;4-(6-AMinopyridin-3-yl)-1-Boc-piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate

CAS:

571188-59-5

MF:

C14H22N4O2

MW:

278.354

EINECS:

1592732-453-0

Product Categories:

PD 0332991;Palbociclib;Anticancer

Mol File:

571188-59-5.mol

image001.gif

 

571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic   acid tert-butyl ester Chemical Properties 

Melting point 

130-132℃

Density:

1.182g/cm3

Boiling Point:

454.066ºC at 760 mmHg

Flash Point:

228.411ºC

Refractive Index:

1.569

Sensitive 

Air Sensitive


571188-59-5 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic   acid tert-butyl ester Usage And Synthesis

Description

1-Boc-4-(6-aminopyridin-3-yl)piperazine is used to prepare pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of cyclin-dependent kinases 4 and 6

Intermediate as

827022-33-3 Palbociclib (PD0332991)   Isethionate,LEE011

 

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Synthesis route

image005_副本.jpg

Reference:

Imaeda, Yasuhiro; Kawamoto, Tetsuji; Tobisu, Mamoru; Konishi, Noriko; Hiroe, Katsuhiko; Kawamura, Masaki; Tanaka, Toshimasa; Kubo, Keiji Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 3125 - 3140

 

image007_副本.jpg

Reference:

1. Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2388 - 2406

2. WO2011/140488 A1, ; WO 2011/140488 A1

 

image009_副本.jpg

Reference:

WO2012/97682 A1

 

571188-59-5   4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester   Preparation Products And Raw materials 

 

Upstream information

tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate; 1-Boc-piperazine; tert-butoxycarbonyl anhydride; 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine;5-Bromo-2-nitropyridine; 5-Fluoro-2-nitropyridine; tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; 1-(6-nitropyridin-3-yl)piperazine; 6-bromo-8-cyclopentyl-2-methanesulfinyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; 8-cyclopentyl-5-methyl-2-methanesulfinyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester;


Downtream information

ethyl 8-cyclopentyl-5-methyl-2-[[5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyridin-2-yl]amino]-7-oxopyrido[2,3-d]pyrimidine-6-carboxylate; tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate; tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; 2-Methyl-2-propanyl 4-(6-{[5-bromo-4-(cyclopentylamino)-2-pyrimid inyl]amino}-3-pyridinyl)-1-piperazinecarboxylate

 

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