31230-17-8 3-Amino-5-methylpyrazole

31230-17-8 3-Amino-5-methylpyrazole

3-Amino-5-methylpyrazole Basic information 3-Amino-5-methylpyrazole Chemical Properties Safety Information 3-Amino-5-methylpyrazole Usage And Synthesis 3-Amino-5-methylpyrazole Preparation Products And Raw materials Upstream information methyl salicylate; acrylonitrile; acetylacetone; Isopropyl...
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Product Details

3-Amino-5-methylpyrazole Basic information

Product Name:

3-Amino-5-methylpyrazole

Synonyms:

TIMTEC-BB SBB004375;BUTTPARK 48\04-98;ART-CHEM-BB B016021;AMINO(3-)-5-METHYLPYRAZOLE;AKOS BBS-00004647;AKOS    B016021;5-METHYL-2H-PYRAZOLE-3-YL AMINE;5-METHYL-2H-PYRAZOL-3-YL AMINE

CAS:

31230-17-8

MF:

C4H7N3

MW:

97.12

EINECS:

-0

Product Categories:

Amines;Pyrazoles & Triazoles;Pyrazole;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Pyrazoles & Triazoles;Benzimidazoles

Mol File:

31230-17-8.mol

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3-Amino-5-methylpyrazole Chemical Properties

Fp 

>230 °F

storage temp. 

-20°C Freezer

solubility 

Soluble in Dichloromethane and    Methanol.

form 

Solid

color 

Light yellow to orange

Appearance:

white to light yellow crystal    powder

Density:

1.221g/cm3

Melting    Point:

41-43ºC

Boiling    Point:

213ºC (14 mmHg)

Flash    Point:

>110ºC

Refractive Index:

1.617

Sensitive 

Air Sensitive

BRN 

1904

Stability:

Light Sensitive

CAS DataBase Reference

31230-17-8(CAS    DataBase Reference)

EPA Substance Registry System

1H-Pyrazol-3-amine,    5-methyl-(31230-17-8)


Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

IRRITANT

Hs code

 


3-Amino-5-methylpyrazole Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Intermediate as

935666-88-9 AZD1480, 905586-69-8 AZ960,1291074-87-7 ENMD-2076 L-(+)-Tartaric acid, 934353-76-1 ENMD-2076,639089-54-6 VX-680 (Tozasertib, MK-0457), 1229236-86-5 LY2784544

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Synthesis route

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Reference:

Sumitomo Chemical Company, Limited Patent: US5384409 A1, 1995

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Reference:

Nam; Grandberg; Sorokin Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 3 p. 281 - 283

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Reference:

Nam; Grandberg; Sorokin Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 11 p. 1371 - 1374

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Reference:

Dorokhov, V. A.; Komkov, A. V.; Ugrak, B. I. Russian Chemical Bulletin, 1993 , vol. 42, # 8 p.1364 - 1368 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1993 , # 8 p. 1429 - 1433


3-Amino-5-methylpyrazole Preparation Products And Raw materials

Preparation Products

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)-->3-Methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine ,97%-->1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)

Raw materials

Etanol-->Sodium    hydroxide-->Hydrochloric    acid-->Nitric    acid-->Potassium    carbonate-->Sodium    carbonate-->Sodium    nitrite-->Triethylamine-->Acetone-->Ammonia-->Hydrazinium    hydroxide-->Diethyl    oxalate-->CARBON    DIOXIDE-->tert-Butanol-->Sodium    hypochlorite-->Sodium    ethoxide-->Benzaldehyde-->1-Pentanol-->Barium    hydroxide octahydrate-->3-Aminocrotononitrile-->Ethyl 2,4-dioxovalerate-->hydrazine    hydrate

 

Upstream information

methyl salicylate; acrylonitrile; acetylacetone; Isopropyl ether; chalcone; 2,4,5-Trichloropyrimidine; 3-Amino-5-methylpyrazole; dibenzoylmethane; 1-Nitroanthraquinone; 3-iminobutanenitrile;


Downtream information

2-cyano-3-(5-methyl-1(2)H-pyrazol-3-ylamino)-acrylic acid ethyl ester; ETHYL 2,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE; Ethyl 7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate; 2-Methylpyrazolo[1,5-a]pyrimidin-7-amine; 2-methyl-1H-pyrazolo[1,5-a]pyrimidin-5-one; 2,5-Dimethylpyrazolo[1,5-a]pyrimidin-7-ol; 3-(5-amino-3-methylpyrazol-1-yl)propanenitrile; 3-Methyl-1H-pyrazolo[3,4-b]pyridine; N-(5-Methyl-1H-pyrazol-3-yl)acetamide; 2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid


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