207557-35-5 (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

207557-35-5 (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Basic information (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Chemical Properties Safety Information MSDS Information (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Usage And Synthesis (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile...
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Product Details

 (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Basic   information

Product Name:

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

Synonyms:

(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile;Vildagliptin interMediate C;vildagliptin Impurity J;cas:207557-35-5;2-Pyrrolidinecarbonitrile, 1-(chloroacetyl)-, (2S)-;(S)-1-(2-CHLOROACETYL)PYRROLIDINE-2-CARBONITRILE;(2S)-1-(CHLOROACETYL)-2-PYRROLIDINECARBONITRILE;(2S)-1-CHLOROACETYLPYRROLIDINE-2-CARBONITRILE

CAS:

207557-35-5

MF:

C7H9ClN2O

MW:

172.61

EINECS:

1592732-453-0

Product Categories:

Pharmaceuticalintermediates;ACETYLHALIDE;intermediate

Mol File:

207557-35-5.mol

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(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Chemical Properties 

Density:

1.273g/cm3

Boiling   Point:

363.149ºC at 760 mmHg

Flash   Point:

173.427ºC

Refractive   Index:

1.519

Vapor   Pressure:

0mmHg at 25°C

 

Safety Information 

Hs coce

2942000000

 

MSDS Information 

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Usage And Synthesis


Chemical Properties

White crystals

Uses

(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile   is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin   (V305000).

Intermediate as

739366-20-2 Anagliptin,   274901-16-5 Vildagliptin

 

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Synthesis route

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Reference:

Peng, Jun; Feng, Yue; Tao, Zhu; Chen,   Yingjie; Hu, Xiangnan Letters in Organic Chemistry, 2013 , vol. 10, # 3 p.   159 - 163

 

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Reference:

ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN,   Venkat Raman; PILLAI, Bijukumar Gopinathan; KEVAT, Jitendra; DUBADIA,   Bhagwati; KAUSHAL, Anupriya Patent: WO2014/20462 A1, 2014 ; Location in   patent: Page/Page column 9

 

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Reference:

1. Journal of Medicinal Chemistry, vol. 46, # 13 p. 2774 - 2789

2. Medichem, S.A. Patent: US2008/167479 A1, 2008 ; Location in patent: Page/Page column 5

 

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Reference:

WO2006/90244 A1, ; Page/Page column 28 ; WO 2006/090244 A1

 

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Preparation Products And Raw materials

 

Related Product Information:

(S)-Pyrrolidine-2-carbonitrile hydrochloride vildagliptin Impurity R vildagliptin Impurity Q Vildagliptin Related Compound F ; vildagliptin Impurity V Vildagliptin (S)-PYRROLIDINE-2-CARBONITRILE chloroacetylaminoacetonitrile 2-CHLORO-1-PYRROLIDIN-1-YL-ETHANONE (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile N-ACETYL-L-TYROSINE ETHYL ESTER 2-Acetyl pyrrole tributyl acetocitrate ;1-Methylpyrrolidine Tetrahydro pyrrole Acetylacetone Chloroacetyl chloride Acetylferrocene

 

Upstream information

Chloroacetyl chloride ; 1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid ; tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate ; (2S)-1-(2-chloroacetyl)pyrrolidine-2-carboxamide ; methyl (2S)-2-pyrrolidinecarboxylate ; D-1-N-Boc-prolinamide ; 3-Amino-1-adamantanol; L-proline ; L-prolinamide; (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile ;


Downtream information

6-[2-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]ethylamino]pyridine 3carbonitrile,dihydrochloride; Vildagliptin; (2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile; (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile



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