18372-22-0 Methyl Indolyl-3-glyoxylate

18372-22-0 Methyl Indolyl-3-glyoxylate

Methyl indolyl-3-glyoxylate Basic information Methyl indolyl-3-glyoxylate Chemical Properties Safety Information Methyl indolyl-3-glyoxylate Usage And Synthesis Methyl indolyl-3-glyoxylate Preparation Products And Raw materials Upstream information indol-1-ylacetamide;...

Product Details

Methyl indolyl-3-glyoxylate Basic information

Product Name:

Methyl    indolyl-3-glyoxylate

Synonyms:

α-Oxo-1H-indole-3-acetic Acid    Methyl Ester;1H-Indole-3-acetic    acid, α-oxo-, Methyl ester;Methyl    2-(indol-3-yl)-2-oxoacetate;Methyl    Indol-3-Glyoxylate;Methyl    3-indoleglyoxylate 98%;(1H-Indol-3-yl)-oxo-acetic    acid methyl ester;2-(1H-indol-3-yl)-2-keto-acetic    acid methyl ester;2-(1H-indol-3-yl)-2-oxoacetic    acid methyl ester

CAS:

18372-22-0

MF:

C11H9NO3

MW:

203.19

EINECS:

 

Product Categories:

Indole;Indole Derivatives;Building Blocks;Heterocyclic Building Blocks;Indoles

Mol File:

18372-22-0.mol

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Methyl indolyl-3-glyoxylate Chemical Properties

form 

Solid

Appearance:

Pale yellow fine powder

Density:

1.324g/cm3

Melting    Point:

227-230ºC

Boiling    Point:

383.2ºC at 760mmHg

Flash    Point:

185.6ºC

Refractive   Index:

1.635

Vapor   Pressure:

4.46E-06mmHg at 25°C

Stability:

Temperature Sensitive

CAS DataBase Reference

18372-22-0(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

Hs code

 


Methyl indolyl-3-glyoxylate Usage And Synthesis

Chemical Properties

Pale Yellow Fine Powder

Uses

Reactant for preparation of    sotrastaurin analogs as protein kinase inhibitors 1 Reactant for synthesis of    GSK-3 inhibitors 2 Reactant for Diels-Alder cycloaddition 3 Reactant for    preparation of a Janus kinase 3 inhibitor 4 Reactant for synthesis of    cephalandole alkaloids 5 Reactant for stereoselective preparation of COX-2    inhibitor as anticancer agent 6 Reactant for synthesis of cycloalkene indole    carbazole alkaloids via ring-closing metathesis.

Intermediate as

425637-18-9 Sotrastaurin,    133052-90-1 GF109203X

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Synthesis route

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Reference:

1. Journal of Organic Chemistry, , vol. 65, #    2 p. 530 - 535
2. European Journal of Medicinal Chemistry,,vol. 34, # 2 p. 161 - 165
3. US2004/102467 A1
4. Journal of Organic Chemistry, , vol. 63, # 17 p.    6053 - 6058

image009_副本.jpg

Reference:

1. Archiv der Pharmazie, , vol. 346, # 5 p.    349 - 358
2. Liebigs Annalen der    Chemie, , p. 901 - 910
3. Tetrahedron Letters, , vol. 39, # 52 p. 9629 - 9630
4. Chemische Berichte, , vol. 57, p. 1455
5. US2004/102467 A1
6. Journal of Organic Chemistry,, vol. 23, p.    1171,1176


Methyl indolyl-3-glyoxylate Preparation Products And Raw materials


Upstream information

indol-1-ylacetamide; 2-(1H-indol-3-yl)-2-oxoacetyl chloride; methyl 2-(1H-indol-3-yl)-2-oxoacetate; Sodium methoxide; 1H-indole; Oxalyl Chloride; indole-3-acetamide; 2-imidazol-1-ylacetamide; methanol; iodomethane;


Downtream information

tryptophol; 3-(2-azidoethyl)-1H-indole; tert-butyl-[2-(1H-indol-3-yl)ethoxy]-dimethylsilane; D,L-3-Indolylglycine Methyl Ester; AMINO-(1H-INDOL-3-YL)-ACETIC ACID; 3,4-bis(1H-indol-3-yl)-1-methylpyrrole-2,5-dione; methyl 2-(1-methylindol-3-yl)-2-oxoacetate; 1H-Indol-3-yl(oxo)acetic acid; INDOLE-3-(N,N-DIMETHYL)GLYOXYLAMIDE; 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione

 

Related Product Information

2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester Methyl acetate Methyl benzoate Methyl acrylate Ethyl glyoxalateMethylparaben Parathion-methyl Methyl salicylate Indole Kresoxim-methyl 2-(1H-INDOL-3-YL)ETHYL 2-(5-BROMO-1H-INDOL-3-YL)-2-OXOACETATE 5-BENZYLOXYINDOLE-3-GLYOXYLIC ACID ETHYL ESTER 7-ETHYLINDOLE-3-GLYOXYLIC ACID ETHYL ESTER METHYL (2-METHYL-1H-INDOL-3-YL)(OXO)ACETATE TERT-BUTYL 3-[ETHOXY(OXO)ACETYL]-1H-INDOLE-1-CARBOXYLATE (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER (1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Methyl indolyl-3-glyoxylate


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