Methyl indolyl-3-glyoxylate Basic information
Product Name: | Methyl indolyl-3-glyoxylate |
Synonyms: | α-Oxo-1H-indole-3-acetic Acid Methyl Ester;1H-Indole-3-acetic acid, α-oxo-, Methyl ester;Methyl 2-(indol-3-yl)-2-oxoacetate;Methyl Indol-3-Glyoxylate;Methyl 3-indoleglyoxylate 98%;(1H-Indol-3-yl)-oxo-acetic acid methyl ester;2-(1H-indol-3-yl)-2-keto-acetic acid methyl ester;2-(1H-indol-3-yl)-2-oxoacetic acid methyl ester |
CAS: | 18372-22-0 |
MF: | C11H9NO3 |
MW: | 203.19 |
EINECS: |
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Product Categories: | Indole;Indole Derivatives;Building Blocks;Heterocyclic Building Blocks;Indoles |
Mol File: | 18372-22-0.mol |
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Methyl indolyl-3-glyoxylate Chemical Properties
form | Solid |
Appearance: | Pale yellow fine powder |
Density: | 1.324g/cm3 |
Melting Point: | 227-230ºC |
Boiling Point: | 383.2ºC at 760mmHg |
Flash Point: | 185.6ºC |
Refractive Index: | 1.635 |
Vapor Pressure: | 4.46E-06mmHg at 25°C |
Stability: | Temperature Sensitive |
CAS DataBase Reference | 18372-22-0(CAS DataBase Reference) |
Safety Information
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
HazardClass | IRRITANT |
Hs code |
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Methyl indolyl-3-glyoxylate Usage And Synthesis
Chemical Properties | Pale Yellow Fine Powder |
Uses | Reactant for preparation of sotrastaurin analogs as protein kinase inhibitors 1 Reactant for synthesis of GSK-3 inhibitors 2 Reactant for Diels-Alder cycloaddition 3 Reactant for preparation of a Janus kinase 3 inhibitor 4 Reactant for synthesis of cephalandole alkaloids 5 Reactant for stereoselective preparation of COX-2 inhibitor as anticancer agent 6 Reactant for synthesis of cycloalkene indole carbazole alkaloids via ring-closing metathesis. |
Intermediate as | 425637-18-9 Sotrastaurin, 133052-90-1 GF109203X
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Synthesis route |
Reference:1. Journal of Organic Chemistry, , vol. 65, # 2 p. 530 - 535
Reference:1. Archiv der Pharmazie, , vol. 346, # 5 p. 349 - 358 |
Methyl indolyl-3-glyoxylate Preparation Products And Raw materials
Upstream information
indol-1-ylacetamide; 2-(1H-indol-3-yl)-2-oxoacetyl chloride; methyl 2-(1H-indol-3-yl)-2-oxoacetate; Sodium methoxide; 1H-indole; Oxalyl Chloride; indole-3-acetamide; 2-imidazol-1-ylacetamide; methanol; iodomethane;
Downtream information
tryptophol; 3-(2-azidoethyl)-1H-indole; tert-butyl-[2-(1H-indol-3-yl)ethoxy]-dimethylsilane; D,L-3-Indolylglycine Methyl Ester; AMINO-(1H-INDOL-3-YL)-ACETIC ACID; 3,4-bis(1H-indol-3-yl)-1-methylpyrrole-2,5-dione; methyl 2-(1-methylindol-3-yl)-2-oxoacetate; 1H-Indol-3-yl(oxo)acetic acid; INDOLE-3-(N,N-DIMETHYL)GLYOXYLAMIDE; 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
Related Product Information
2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester Methyl acetate Methyl benzoate Methyl acrylate Ethyl glyoxalateMethylparaben Parathion-methyl Methyl salicylate Indole Kresoxim-methyl 2-(1H-INDOL-3-YL)ETHYL 2-(5-BROMO-1H-INDOL-3-YL)-2-OXOACETATE 5-BENZYLOXYINDOLE-3-GLYOXYLIC ACID ETHYL ESTER 7-ETHYLINDOLE-3-GLYOXYLIC ACID ETHYL ESTER METHYL (2-METHYL-1H-INDOL-3-YL)(OXO)ACETATE TERT-BUTYL 3-[ETHOXY(OXO)ACETYL]-1H-INDOLE-1-CARBOXYLATE (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER (1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Methyl indolyl-3-glyoxylate
