183208-35-7 5-Bromo-7-azaindole

183208-35-7 5-Bromo-7-azaindole

5-Bromo-7-azaindole Basic information 5-Bromo-7-azaindole Chemical Properties Safety Information 5-Bromo-7-azaindole Usage And Synthesis 5-Bromo-7-azaindole Preparation Products And Raw materials Upstream information 3-Pyridylboronic acid; Triisopropylsilyl Chloride; 2-bromoacetyl chloride;...
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Product Details

5-Bromo-7-azaindole Basic information

Product Name:

5-Bromo-7-azaindole

Synonyms:

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;5-BROMO-7-AZAINDOLE;5-BROMO AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine,    5-bromo-;5-Bromo-1H-pyrrolo2,3-büpyridine;3-Bromo-7H-pyrrolo[2,3-b]pyridine;5-Bromo-1H-pyrrolo[2,3-b]pyridine ,97%;5-Bromo-7-azaindole 97%

CAS:

183208-35-7

MF:

C7H5BrN2

MW:

197.03

EINECS:

1308068-626-2

Product Categories:

Heterocycles;CHIRAL CHEMICALS;pyridine;Non-Chiral heterocyclic    compounds;Heterocycle-Indole    series;Heterocycle-Pyridine    series

Mol File:

183208-35-7.mol

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5-Bromo-7-azaindole Chemical Properties

Density:

1.77 g/cm3

Melting   Point:

169-179ºC

Refractive   Index:

1.728

storage temp. 

Room temperature.

form 

Crystalline Powder

color 

White to yellow

CAS DataBase Reference

183208-35-7(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-41

Safety Statements 

26-39

HazardClass 

IRRITANT

Hs code

2933990090


5-Bromo-7-azaindole Usage And Synthesis

Chemical Properties

White to light brown powder or  crystal

Intermediate as

1257044-40-8 Venetoclax (ABT-199,   GDC-0199), 1262985-23-8 QC-1075

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Synthesis route

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Reference:

EISAI LONDON RESEARCH LABORATORIES LIMITED    Patent: WO2004/78757 A2, 2004 ; Location in patent: Page 65; 66-67

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Reference:

Barl, Nadja M.; Sansiaume-Dagousset, Elodie;    Karaghiosoff, Konstantin; Knochel, Paul Angewandte Chemie - International    Edition, 2013 , vol. 52, # 38 p. 10093 - 10096 Angew. Chem., 2013 , vol. 52,    # 38 p. 10093 - 10096,4

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Reference:

Hildbrand, Stefan; Mair, Hans-Juergen;    Radinov, Roumen Nikolaev; Ren, Yi; Wright, James Anderson Patent:    US2011/28511 A1, 2011 ; Location in patent: Page/Page column 12-13

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Reference:

SGX Pharmaceuticals, Inc. Patent:    US2006/30583 A1, 2006 ; Location in patent: Page/Page column 75 ; US    20060030583 A1

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Reference:

Wu, Pei-Wen; Hsieh, Wan-Ting; Cheng, Yi-Ming; Wei, Ching-Yen; Chou, Pi-Tai Journal of the American Chemical Society, 2006 , vol. 128, # 45 p. 14426 - 14427

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Reference:

US2011/144105 A1

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Reference:

WO2012/10538 A2

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Reference:

Heterocycles, , vol. 60, # 4 p. 865 - 877

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Reference:

Journal of the American Chemical Society, , vol. 128, # 45 p. 14426 - 14427


5-Bromo-7-azaindole Preparation Products And Raw materials

Raw materials

Acetic    acid glacial-->Bromine-->ZINC-->tert-Butanol-->Boron    trifluoride etherate-->7-Azaindole-->Manganese triacetate dihydrate


Upstream information

3-Pyridylboronic acid; Triisopropylsilyl Chloride; 2-bromoacetyl chloride; carbon monoxide; 5-bromo-3-ethynylpyridin-2-amine; 7-Azaindole; 3,4-Dimethoxyphenylboronic Acid; methyl formate; Sodium cyanide; 2-Amino-5-bromopyridine;


Downtream information

5-Methoxy-1H-pyrrolo[2,3-b]pyridine; 5-ethynyl-1H-pyrrolo[2,3-b]pyridine; 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE; 5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine; 5-(6-methoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine; 5-phenyl-1H-pyrrolo[2,3-b]pyridine; 5-phenylsulfanyl-1H-pyrrolo[2,3-b]pyridine;1-(benzenesulfonyl)-5-bromo-3-iodopyrrolo[2,3-b]pyridine; 1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone; methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate

 

Related Product Information

1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-bromo-6-methyl- 5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER 5-Bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- 1-BENZENESULFONYL-5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-BROMO-3-FORMYL-6-METHYL-7-AZAINDOLE 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-6-methyl- 5-BROMO-3-IODO-6-METHYL-7-AZAINDOLE 5-BROMO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER 5-BROMO-6-METHYL-3-NITRO-7-AZAINDOLE 5-Bromo-7-azaindole 1-Methyl-2-pyrrolidinone Indometacin N-Vinyl-2-pyrrolidone Bromine 3-Indolebutyric acid 1-(2,6-Dichlorophenyl)indolin-2-one

 

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