1072-67-9 3-Amino-5-methylisoxazole

1072-67-9 3-Amino-5-methylisoxazole

3-Amino-5-methylisoxazole Basic information 3-Amino-5-methylisoxazole Chemical Properties Safety Information 3-Amino-5-methylisoxazole Usage And Synthesis 3-Amino-5-methylisoxazole Preparation Products And Raw materials Upstream information 2-bromoacetyl chloride; thiophosgene;...
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Product Details

3-Amino-5-methylisoxazole Basic information

Product Name:

3-Amino-5-methylisoxazole

Synonyms:

3-Isoxazolamine,5-methyl-;3-Methyl-5-aminoisoxazole;5-Methyl-3-aminoisoxazole;5-methyl-3-isoxazolamin;5-Methyl-3-isoxazolamine;5-Methyl-3-iso-xazolamine;Isoxazole, 3-amino-5-methyl-;TIMTEC-BB SBB005553

CAS:

1072-67-9

MF:

C4H6N2O

MW:

98.1

EINECS:

214-013-6

Product Categories:

Oxazole&Isoxazole;Building Blocks;Heterocyclic Building Blocks;Isoxazoles;Amines;Heterocycles;Impurities;Intermediates & Fine    Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Amines, Heterocycles,Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur &Selenium Compounds

Mol File:

1072-67-9.mol

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3-Amino-5-methylisoxazole Chemical Properties

solubility 

soluble

PH

6.0-7.5 (10g/l, H2O, 20℃)

Water Solubility 

soluble

Appearance:

slightly yellow flakes

Density:

1.167 g/cm3

Melting    Point:

59-63ºC

Boiling    Point:

235.9ºC at 760 mmHg

Flash    Point:

96.5ºC

Refractive   Index:

1.524

Water   Solubility:

soluble

Stability:

Stable under normal temperatures    and pressures.

Storage   Condition:

Refrigerator

Vapor   Pressure:

0.0487mmHg at 25°C

CAS DataBase Reference

1072-67-9(CAS    DataBase Reference)

NIST Chemistry Reference

3-Isoxazolamine,    5-methyl-(1072-67-9)

EPA Substance Registry System

3-Isoxazolamine,    5-methyl-(1072-67-9)


Safety Information

Hazard Codes 

Xi-F,Xi,F,Xn

Risk Statements 

5-36/37/38-11-36/37/38/5-20/21/22

Safety Statements 

22-24/25-47-37/39-26-16-26/37/39/47-36

WGK Germany 

3

4.6

Hazard Note 

Irritant

HS Code 

29349990


3-Amino-5-methylisoxazole Usage And Synthesis

Chemical Properties

yellow crystalline powder,    crystals and chunks

Uses

Sulfamethoxazole (SMX) (S699086) Impurity. A degradation product in water by a bioluminescence method during application of the electro-Fenton treatment.

Intermediate as

501925-31-1 PNU-120596,475108-18-0 Tivozanib (AV-951), 34552-84-6 Isoxicam

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Synthesis route

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Reference:

Sugai; Sato; Kataoka; et al. Chemical and  Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 530 - 537

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Reference:

Monatshefte fuer Chemie, , vol. 101, p. 1109  - 1122

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Reference:

Shionogi Kenkyusho Nenpo, , # 7 p. 301,304   Chem.Abstr., , p. 17889 US2888455

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Reference:

Shionogi Kenkyusho Nenpo, , # 7 p. 301,304  Chem.Abstr., , p. 17889 US2888455

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Reference:

Journal of the Chemical Society, Perkin  Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 17 - 20


3-Amino-5-methylisoxazole Preparation Products And Raw materials

Preparation Products

naphthol    AS-RS

Raw materials

Etanol-->Hydrochloric    acid-->Ethyl    acetate-->Tetrahydrofuran-->Acetic    acid glacial-->Sodium    nitrite-->Hydrazine    hydrate-->Sodium    hypochlorite-->1,2-Dichlorobenzene-->Potassium    phthalimide-->Methyl    vinyl ketone-->5-Methylisoxazole


Upstream information

2-bromoacetyl chloride; thiophosgene; (Z)-4-((5-methylisoxazol-3-yl)amino)pent-3-en-2-one; 3,5-Dichlorosalicylaldehyde; 4-Methoxybenzoyl chloride; Acetic anhydride; phenyl isothiocyanate; Ethyl malonyl chloride; 2-Methylbenzyl Alcohol; diphenyl carbonate;


Downtream information

1-(5-anilino-1,2,4-thiadiazol-3-yl)propan-2-one; 4-methoxy-N-(5-methyl-1,2-oxazol-3-yl)benzamide; ethyl 3-[(5-methyl-1,2-oxazol-3-yl)amino]-3-oxopropanoate; 1-(4-chlorophenyl)-3-(5-methylisoxazol-3-yl)urea; 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea; 1-(2,6-dimethylphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea; N-(5-methyl-1,2-oxazol-3-yl)acetamide; phenyl N-(5-methyl-1,2-oxazol-3-yl)carbamate; 6-[[(5-methyl-1,2-oxazol-3-yl)amino]methylidene]cyclohexa-2,4-dien-1-one; 3-Isothiocyanato-5-methyl-1,2-oxazole

 

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