3262-72-4 BOC-L-Serine

3262-72-4 BOC-L-Serine

BOC-L-Serine Basic information BOC-L-Serine Chemical Properties Safety Information BOC-L-Serine Usage And Synthesis BOC-L-Serine Preparation Products And Raw materials Upstream information Potassium carbonate; L-serine; N,O-Dimethylhydroxylamine hydrochloride;...
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Product Details

BOC-L-Serine Basic information

Product Name:

BOC-L-Serine

Synonyms:

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI);Boc-Ser-OH   Synonyms:Boc-L-serine;N-ALPHA-T-BUTYLOXYCARBONYL-L-SERINE;BOC-L-PROLINOL LIQUID;N-[(1,1-DIMETHYLETHOXY)CARBONYL]- L-SERINE;N-Boc-L-serine, 98%(dry wt.), may cont. up to 10% water;BOC-L-SERINE    extrapure;N-(tert-Butoxycarbonyl)-L-serine,Boc-L-serine

CAS:

3262-72-4

MF:

C8H15NO5

MW:

205.21

EINECS:

221-867-3

Product Categories:

N-BOC;Amino Acid Derivatives;Amino Acids;Serine [Ser, S];Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series

Mol File:

3262-72-4.mol

image001.gif


BOC-L-Serine Chemical Properties

alpha 

-7.5 º (c=2, water)

form 

Powder

color 

White

Water Solubility 

almost transparency

Appearance:

White to off-white crystalline    powder

Density:

1.24 g/cm3

Melting    Point:

46-52ºC

Boiling    Point:

385ºC

Refractive   Index:

-4 ° (C=1, AcOH)

Stability:

Stable under normal temperatures    and pressures.

Storage   Condition:

2-8ºC

BRN 

2212252

InChIKey

FHOAKXBXYSJBGX-YFKPBYRVSA-N

CAS DataBase Reference

3262-72-4(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

Hs code

2924199090


BOC-L-Serine Usage And Synthesis

Chemical Properties

white to light brown powder

Description

N-Boc-L-serine is an N-Boc-protected form of L-Serine.    L-Serine is a nonessential amino acid that is required for the synthesis of    sphingolipids and phosphatidylserine, compounds that are important for    central nervous system neuronal survival. L-Serine is also important in    intermediary metabolism in eukaryotic cells.

Uses

Starting material for the    synthesis of various a-amino acids via the b-lactone

Intermediate as

159752-10-0 MK677(mesylate salt)

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Sytnehesis route

image005_副本.jpg

Reference:

Galaffu, Nicola; Man, Siud Pui; Wilkes, Robin    D.; Wilson, John R. H. Organic Process Research and Development, 2007 , vol.    11, # 3 p. 406 - 413
       Rizo, Josep; Albericio, Fernando; Romero, Guillermo;    Garcia-Echeverria, Carlos; Claret, Josep; et al. Journal of Organic    Chemistry, 1988 , vol. 53, # 22 p. 5386 - 5389

image007_副本.jpg

Reference:

Sinha, Manish; Dola, Vasanth R.; Agarwal,Pooja; Srivastava, Kumkum; Haq, Wahajul; Puri,Sunil K.;Katti, Seturam B.Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 14 p. 3573 - 3586
Kim, Sunggak; Lee, Jae In Chemistry Letters, 1984 , p. 237 - 238
Nimkar; Menaldino;Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040

image009_副本.jpg

Reference:

Marcantoni; Massaccesi; Torregiani; Bartoli; Bosco; Sambri Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4430 - 4432


BOC-L-Serine Preparation Products And Raw materials

Preparation Products

N-BOC-O-Benzyl-L-serine


Upstream information

Potassium carbonate; L-serine; N,O-Dimethylhydroxylamine hydrochloride; 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile; allyl alcohol;iodomethylbenzene; chloro(dimethoxy)phosphane; tert-butyl quinolin-8-yl carbonate; benzyl alcohol; tert-butyl carbonochloridate;


Downtream information

(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid; tert-butyl N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]carbamate; (S)-tert-Butyl 4-(methoxy(methyl)carbamoyl)-2,2-dimethyloxazolidine-3-carboxylate; BOC-O-BENZYL-L-SERINE N,O-DIMETHYLHYDROXAMIDE; Boc-D-Serine Benzylamide; (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid; (S)-N-Boc-2-Amino-3-Methoxy-Propionic Acid; Methyl N-Boc-N-(2-benzyloxyethyl)-2-aminoacrylate; N-(N-Boc-L-seryl)-2-aminoethanol; tert-butyl 2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate

 

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