5337-03-1 Tetrahydro-2H-pyran-4-carboxylic Acid

5337-03-1 Tetrahydro-2H-pyran-4-carboxylic Acid

Tetrahydro-2H-pyran-4-carboxylic acid Basic information Tetrahydro-2H-pyran-4-carboxylic acid Chemical Properties Safety Information Tetrahydro-2H-pyran-4-carboxylic acid Usage And Synthesis Tetrahydro-2H-pyran-4-carboxylic acid Preparation Products And Raw materials Upstream information Water;...
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Product Details

Tetrahydro-2H-pyran-4-carboxylic acid Basic information

Product   Name:

Tetrahydro-2H-pyran-4-carboxylic acid

Synonyms:

CHEMBRDG-BB 4004296; ASINEX-REAG BAS 06502515;TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID; TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID;TETRAHYDRO-2H-PYRAN-4-YL-CARBOXYLIC ACID;Tetrahydro-2H-pyrane-4-carboxylicacid;Terahydropyran-4-yl-carboxylic acid;Tetrahydro-2H-pyran-4-carboxylic acid 98%

CAS:

5337-03-1

MF:

C6H10O3

MW:

130.14

EINECS:

1592732-453-0

Product   Categories:

blocks;Carboxes;Heterocycles;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Building Blocks;Pyran;Carboxylic Acids;Pyrans, Piperidines & Piperazines;organic intermediate

Mol File:

5337-03-1.mol

image001.gif

 

Tetrahydro-2H-pyran-4-carboxylic   acid Chemical Properties 

form 

Solid

color 

White to off-white

Appearance:

white to light yellow crystal powder

Density:

1.185 g/cm3

Melting Point:

87-89ºC

Boiling Point:

264.5ºC at 760 mmHg

Flash Point:

114ºC

CAS DataBase Reference

5337-03-1(CAS DataBase Reference)

 

Safety Information 

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22-20/21/22

Safety   Statements 

26-36/37/39-22-39-24/25

RIDADR 

2811

Hazard Note 

Irritant

HazardClass 

IRRITANT

Hs code

2932999099

 

Tetrahydro-2H-pyran-4-carboxylic acid Usage And Synthesis

Chemical   Properties

white to light yellow crystal powder

Intermediate   as


Synthesis   route

image003_副本.jpg

Reference:

Kim, In-Hae; Park, Yong-Kyu; Hammock, Bruce D.; Nishi, Kosuke Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1752   - 1761

 

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Reference:

Straessler, Christoph; Linden, Anthony; Heimgartner, Heinz Helvetica Chimica Acta, 1997 , vol. 80, # 5 p. 1528 - 1551

 

image007_副本.jpg

Reference:

UBE INDUSTRIES, LTD. Patent: US2008/306287 A1, 2008 ; Location in patent: Page/Page column 5

 

image009_副本.jpg

Reference:

1. Helvetica Chimica Acta, , vol. 80, # 5 p. 1528 - 1551

2. EP1577301 A1, ; Page/Page column 146-147 

 

image011_副本.jpg

Reference:

Journal of Organic Chemistry, , vol. 71, # 18 p. 7035 - 7044

 

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Reference:

Morris, David J.; Hayes, Aidan M.; Wills, Martin Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7035 - 7044

 

Tetrahydro-2H-pyran-4-carboxylic acid Preparation Products And Raw materials 

Raw   materials

Etanol-->Hydrochloric acid-->Ethyl acetate-->Sodium-->Potassium hydroxide -->Acetone-->Hexane-->Diethyl malonate-->2,2'-Dichlorodiethyl ether

Preparation Products

Tetrahydropyran-4-carbaldehyde-->4-BROMOMETHYLTETRAHYDROPYRAN-->4-(2-AMINOETHYL)TETRAHYDROPYRAN-->(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL-->(TETRAHYDRO-PYRAN-4-YL)-ACETONITRILE-->TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE-->Tetrahydropyranyl-4-acetic acid

 

Upstream information

Water; N, O-Dimethylhydroxylamine hydrochloride; Diethyl malonate; methyl 4-cyanooxane-4-carboxylate; Methyl tetrahydro-2H-pyran-4-carboxylate; Tetrahydropyran-4-carboxylic Acid; 2, 2'-Dichlorodiethyl ether; Ethanol; 4-Formyltetrahydropyran; 4-(methoxymethylidene)oxane;


Downtream information

4-Bromomethyltetrahydropyran; methyl thiane-4-carboxylate; 2-bromo-1-(oxan-4-yl)ethanone; 4-isocyanatooxane; oxane-4-carboxamide; octahydro-[4,4']bipyranyl; Tetrahydro-2H-pyran-4-carbonyl chloride; Methyl tetrahydro-2H-pyran-4-carboxylate; (Tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate; 4-methyloxane-4-carboxylic acid


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