Tetrahydro-2H-pyran-4-carboxylic acid Basic information
Product Name: | Tetrahydro-2H-pyran-4-carboxylic acid |
Synonyms: | CHEMBRDG-BB 4004296; ASINEX-REAG BAS 06502515;TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID; TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID;TETRAHYDRO-2H-PYRAN-4-YL-CARBOXYLIC ACID;Tetrahydro-2H-pyrane-4-carboxylicacid;Terahydropyran-4-yl-carboxylic acid;Tetrahydro-2H-pyran-4-carboxylic acid 98% |
CAS: | 5337-03-1 |
MF: | C6H10O3 |
MW: | 130.14 |
EINECS: | 1592732-453-0 |
Product Categories: | blocks;Carboxes;Heterocycles;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Building Blocks;Pyran;Carboxylic Acids;Pyrans, Piperidines & Piperazines;organic intermediate |
Mol File: | 5337-03-1.mol |
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Tetrahydro-2H-pyran-4-carboxylic acid Chemical Properties
form | Solid |
color | White to off-white |
Appearance: | white to light yellow crystal powder |
Density: | 1.185 g/cm3 |
Melting Point: | 87-89ºC |
Boiling Point: | 264.5ºC at 760 mmHg |
Flash Point: | 114ºC |
CAS DataBase Reference | 5337-03-1(CAS DataBase Reference) |
Safety Information
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-41-37/38-22-20/21/22 |
Safety Statements | 26-36/37/39-22-39-24/25 |
RIDADR | 2811 |
Hazard Note | Irritant |
HazardClass | IRRITANT |
Hs code | 2932999099 |
Tetrahydro-2H-pyran-4-carboxylic acid Usage And Synthesis
Chemical Properties | white to light yellow crystal powder |
Intermediate as | |
Synthesis route |
Reference:Kim, In-Hae; Park, Yong-Kyu; Hammock, Bruce D.; Nishi, Kosuke Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1752 - 1761
Reference:Straessler, Christoph; Linden, Anthony; Heimgartner, Heinz Helvetica Chimica Acta, 1997 , vol. 80, # 5 p. 1528 - 1551
Reference:UBE INDUSTRIES, LTD. Patent: US2008/306287 A1, 2008 ; Location in patent: Page/Page column 5
Reference:1. Helvetica Chimica Acta, , vol. 80, # 5 p. 1528 - 1551 2. EP1577301 A1, ; Page/Page column 146-147
Reference:Journal of Organic Chemistry, , vol. 71, # 18 p. 7035 - 7044
Reference:Morris, David J.; Hayes, Aidan M.; Wills, Martin Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7035 - 7044 |
Tetrahydro-2H-pyran-4-carboxylic acid Preparation Products And Raw materials
Raw materials | Etanol-->Hydrochloric acid-->Ethyl acetate-->Sodium-->Potassium hydroxide -->Acetone-->Hexane-->Diethyl malonate-->2,2'-Dichlorodiethyl ether |
Preparation Products | Tetrahydropyran-4-carbaldehyde-->4-BROMOMETHYLTETRAHYDROPYRAN-->4-(2-AMINOETHYL)TETRAHYDROPYRAN-->(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL-->(TETRAHYDRO-PYRAN-4-YL)-ACETONITRILE-->TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE-->Tetrahydropyranyl-4-acetic acid |
Upstream information
Water; N, O-Dimethylhydroxylamine hydrochloride; Diethyl malonate; methyl 4-cyanooxane-4-carboxylate; Methyl tetrahydro-2H-pyran-4-carboxylate; Tetrahydropyran-4-carboxylic Acid; 2, 2'-Dichlorodiethyl ether; Ethanol; 4-Formyltetrahydropyran; 4-(methoxymethylidene)oxane;
Downtream information
4-Bromomethyltetrahydropyran; methyl thiane-4-carboxylate; 2-bromo-1-(oxan-4-yl)ethanone; 4-isocyanatooxane; oxane-4-carboxamide; octahydro-[4,4']bipyranyl; Tetrahydro-2H-pyran-4-carbonyl chloride; Methyl tetrahydro-2H-pyran-4-carboxylate; (Tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate; 4-methyloxane-4-carboxylic acid
