Fluorine-containing pyridine intermediates become hot spots At present, our country has developed and has been put into mass production of quinolones antibacterial drugs mainly include norfloxacin, ciprofloxacin, Ofloxacin, Norfloxacin, Lomefloxacin, fleroxacin and so on.
Among them, Norfloxacin, ciprofloxacin and Ofloxacin produced the largest production, accounting for about 98% of the total production of fluoroquinolones in China. Quinolones are generally synthesized from fluorine-containing benzene ring by synthesis of quinoline-containing compounds with piperazine (or methyl piperazine). Because of China's abundant fluorite reserves, it is one of the countries with the largest production of fluorine-containing drugs and intermediates in the world, with more than 80% of the fluoride intermediates supplied for export. As a whole, the development of fluorine-benzene intermediates in China is earlier, at present, there is a general surplus of production capacity, the development of three fluorine-toluene intermediates is relatively late, and the development speed is faster in recent years; for heterocyclic aromatic compounds, especially fluorine-containing pyridine, only individual research units and manufacturers have the synthesis technology of fluorine-containing pyridine intermediates.
Fluorine-containing pyridine intermediates will become one of the main research directions of fluorine-containing intermediates in the coming years.
The gap between P-Aminophenol is larger China has become the world's largest producer of antipyretic and analgesic drugs, aspirin, paracetamol, an naijin and other varieties of the production of more than million tons, not that the West Ding, ammonia Kibilin, antipyrine and other varieties of production more than 1000 tons. At present, the production of antipyretic analgesics in China is growing rapidly, and it is expected to grow at around 8% in the future. The production of intermediates for antipyretic and analgesic drugs is large, and many enterprises are produced.
With the growth of antipyretic and analgesic drugs, the intermediates have been developed rapidly. 2003 domestic paracetamol consumption increased rapidly, exports also showed a rapid growth momentum, export volume of 28163 tons, the annual export volume rose by about 1 time times. Its export growth slowed in the first half of 2004, but it still grew, with 12501 tonnes of acetaminophen exports in 2004 1 to May, slightly above the same period last year. Acetaminophen is an important intermediate in the synthesis of paracetamol, and has also grown rapidly in recent years.
At present, the annual production of paracetamol in China is about 32,000 tons, it is expected that by 2005, the domestic paracetamol production will reach more than 50,000 tons, the pharmaceutical industry will consume 45,000 tons of acetaminophen, plus in other areas of application, the total demand for amino phenol in 2005 is about 50,000 tons, the market gap is larger, development and utilization prospects are broad.