79099-07-3 N-BOC-4-piperidone

79099-07-3 N-BOC-4-piperidone

N-(tert-Butoxycarbonyl)-4-piperidone Basic information N-(tert-Butoxycarbonyl)-4-piperidone Chemical Properties Safety Information MSDS Information N-(tert-Butoxycarbonyl)-4-piperidone Usage And Synthesis N-(tert-Butoxycarbonyl)-4-piperidone Preparation Products And Raw materials Upstream...
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Product Details

N-(tert-Butoxycarbonyl)-4-piperidone Basic information

Product Name:

N-(tert-Butoxycarbonyl) -4-piperidone

Synonyms:

BOC-4-PIPERIDONE; BOC-PPD; BOC-PIPERIDONE; 1-BOC-PIPERIDIN-4-ONE; 1-BOC-4-PIPERIDINONE; 1-BOC-4-PIPERIDONE; 1-N-BOC-4-PIPERIDONE; N-Boc-4-piperidone, tert-Butyl 4-oxo-1-piperidinecarboxylate

CAS:

79099-07-3

MF:

C10H17NO3

MW:

199.25

EINECS:

1308068-626-2

Product Categories:

Piperidines; Amino Acids & Derivatives; Pyrans, Piperidines & Piperazines; Amines; blocks; Carbonyl Compounds; Heterocycles; Miscellaneous Biochemicals; pharmacetical; Pyrans, Piperidines &Piperazines; Piperidine; Piperidine Series

Mol File:

79099-07-3.mol

image001_副本.jpg


N-(tert-Butoxycarbonyl)-4-piperidone Chemical   Properties

Melting point

73-77 °C(lit.)

Density:

1.099 g/cm3

Melting Point:

73-77ºC

Boiling Point:

289.8ºC at 760 mmHg

Flash Point:

129.1ºC

Refractive Index:

1.481

storage temp.

Store at 0-5°C

form

Crystalline Powder

color

White to slightly yellow

Appearance:

White or light yellow coloured powder

Water Solubility

slightly soluble

BRN

3650236

CAS DataBase Reference

79099-07-3(CAS DataBase Reference)


Safety Information

Hazard Codes

Xn, Xi

Risk Statements

36/38-22-36/37/38-20/21/22

Safety Statements

37/39-26-36-24/25

WGK Germany

3

Hazard Note

Irritant

HazardClass

IRRITANT

Hs code

2933399090


MSDS Information


N-(tert-Butoxycarbonyl)-4-piperidone Usage And Synthesis

Chemical Properties

Light Yellow Powder

Synthesis route

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Reference:

1. Pfizer Inc. Patent: US6414149 B1, 2002

2. Planty, Bruno; Pujol, Chantal; Lamothe, Marie; Maraval, Catherine; Horn, Clemens; Grand, Bruno Le; Perez, Michel Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1735 – 1739

3. Schering Corporation Patent: US2004/266810 A1, 2004 ; Location in patent: Page/Page column 6

4. XENON PHARMACEUTICALS INC. Patent: WO2006/34338 A1, 2006 ; Location in patent: Page/Page column 50 ; WO 2006/034338 A1

5. Obase, Hiroyuki; Nakamizo, Nobuhiro; Takai, Haruki; Teranishi, Masayuki Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2853 – 2854

6. Chemical and Pharmaceutical   Bulletin, 1983 , vol. 31, # 9 p. 3186 – 3197

7. US6306882 B1


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Reference:

1. COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; YANG, Qi; JAMES, Susan N.; BALLARD, Mathew John; BOWN, Mark; FERON, Paul; PUXTY, Graeme   Douglas Patent: WO2012/142668 A1, 2012 ; Location in patent: Page/Page column   50; 51

2. PIRAMAL LIFE SCIENCES   LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan Patent:   WO2011/104680 A1, 2011 ; Location in patent: Page/Page column 73 ; WO 2011/104680 A1

3. Fan, Xing; Zhang, Feng-Hua; Al-Safi, Rasha I.; Zeng, Li-Fan; Shabaik, Yumna; Debnath, Bikash; Sanchez, Tino W.; Odde, Srinivas; Neamati, Nouri; Long, Ya-Qiu Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4935 – 4952

4. Hoffmann-La Roche Inc.; Hermann, Johannes Cornelius; Kuglstatter, Andreas; Lucas, Matthew C.; Padilla, Fernando; Wanner, Jutta; Zhang, Xiaohu Patent: US2013/109661 A1, 2013 ; Location in patent: Paragraph 0613-0614

5. US6107308 A1

6. EP976722 A1


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Reference:

Berini, Christophe; Winkelmann, Ole H.; Otten, Jennifer; Vicic, David A.; Navarro, Oscar Chemistry - A European Journal, 2010 , vol. 16, # 23 p. 6857 – 6860


image009_副本.jpg

Reference:

Chandrasekhar; Babu, B. Nagendra; Reddy, Ch. Raji Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2057 - 2059


N-(tert-Butoxycarbonyl)-4-piperidone Preparation Products And Raw materials


Upstream information

methyl (S) -6-bromo-5-(3-ethylpiperazin-1-yl) picolinate; m-trifluoro-methyl-phenyl-magnesium bromide; 1, 1, 1-Trifluoro-N-phenylmethanesulfonamide; 2-chloroethyl(dimethyl) sulfanium, iodide; 2-Chlorobenzylamine; 1-(5-Fluoro-2-hydroxyphenyl) -1-ethanone; piperidin-4-one; 2-METHOXYETHYLAMINE; 7-Azaindole; 3-Bromochlorobenzene;


Downtream information

(1-tert-butoxycarbonyl-1, 2, 5, 6-tetrahydropyridin-4-yl) acetic acid ethyl ester; tert-butyl 2-phenyl-6, 7-dihydro-2H-pyrazolo[4, 3-c] pyridine-5(4H) -carboxylate; 4-((R) -3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl) -[1, 4'] bipiperidinyl-1'-carboxylic acid tert-butyl ester; tert-butyl 4-hydroxy-4-(2-methoxyphenyl) piperidine-1-carboxylate; tert-butyl 4-pyridin-2-ylpiperidine-1-carboxylate; 2-Methyl-2-propanyl 4-(4-bromobenzyl) -1,4'-bipiperidine-1'-carbox ylate; tert-butyl 6-cyano-5-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; tert-butyl 2-tert-butyl-7-oxospiro[6H-pyrano[3, 2-c]pyrazole-5, 4'-piperidine] -1'-carboxylate; tert-butyl 3-methyl-2, 4 , 6, 7-tetrahydropyrazolo[4, 3-c]pyridine-5-carboxylate; tert-butyl 4-hydroxy-4-[3-(trifluoromethyl) phenyl]piperidine-1-carboxylate;


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