1-Methylpiperidin-4-amine Basic information
Product Name: | 1-Methylpiperidin-4-amine |
Synonyms: | 1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE; 4-Amino-1-methylpiperdine; 1-Methyl-4-Amino Piperidine; 4-AMINO-1-METHYLPIPERDINE, 98.5%; 1-Methylpiperidin-4-amine; 4-Amino-1-methylpiperidine; N-Methyl-4-aminopiperidine; 4-Amino-1-methylpiperidine, 97% |
CAS: | 41838-46-4 |
MF: | C6H14N2 |
MW: | 114.19 |
EINECS: | |
Product Categories: | Pyridine; API intermediates; API intermediate |
Mol File: | 41838-46-4.mol |
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1-Methylpiperidin-4-amine Chemical Properties
Appearance: | colorless to light-yellow liquid |
Density: | 0.912 g/cm3 |
Melting Point: | 203-207ºC |
Boiling Point: | 55 - 60 °C at 15mmHg; 70 - 71 °C at 35mmHg |
Flash Point: | 39.2ºC |
density | 0.91 |
refractive index | 1.4700-1.4740 |
CAS DataBase Reference | 41838-46-4(CAS DataBase Reference) |
Safety Information
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-22-34-11 |
Safety Statements | 26-36/37/39-45-22-16-9 |
RIDADR | 2920 |
Hazard Note | Irritant |
HazardClass | IRRITANT |
PackingGroup | Ⅱ |
Hs code | 2933990090 |
MSDS Information
1-Methylpiperidin-4-amine Usage And Synthesis
Chemical Properties | Clear colorless to yellow liquid |
Intermediate as | 934541-31-8 TAK-901， 1253584-84-7 NMS-E973， 755038-02-9 BI 2536
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Synthesis route |
Reference: AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara Patent: WO2012/59932 A1, 2012 ; Location in patent: Page/Page column 137 ; WO 2012/059932 A1
Reference: SMITHKLINE BEECHAM CORPORATION Patent: EP1229035 A1, 2002 ; Location in patent: Page 33 ; Title/Abstract Full Text Show Details SMITHKLINE BEECHAM CORPORATION Patent: EP1227091 A2, 2002 ; Location in patent: Page 33
Reference: ACADIA PHARMACEUTICALS, INC. Patent: WO2007/124136 A1, 2007 ; Location in patent: Page/Page column 126-127 ; WO 2007/124136 A1
Reference: 1. Pau, Amedeo; Boatto, Gianpiero; Cerri, Riccardo; Palagiano, Francesco; Filippelli, Walter; Falcone, Giuseppe; Lampa, Enrico Farmaco, 1998 , vol. 53, # 3 p. 233 – 240 2. Brookes et al. Journal of the Chemical Society, 1957 , p. 3165,3171 |
1-Methylpiperidin-4-amine Preparation Products And Raw materials
Raw materials | Methanol-->Thionyl chloride-->Bromine-->Potassium hydroxide -->Ammonium hydroxide-->Formaldehyde-->Formic acid-->Isonipecotic acid |
Upstream information
3-Methoxy-4-nitrobenzoic acid; 1-benzyl-2-chlorobenzimidazole; N-((4-methylphenyl) methyl)-N-(1-piperidin-4-yl) -4-chlorophenylacetamide; Ethanol; Methyl 1-methyl-4-oxopiperidine-3-carboxylate; 1-Methyl-4-piperidone; 4-(chlorocarbonyl) -4, 9-dihydro-1, 3-dimethyl-10H-thieno[3, 4-b][1, 5] benzodiazepin-10-one; 1-Methyl-4-piperidone Oxime Hydrochloride; N- (1-methylpiperidin-4-ylidene) hydroxylamine; 1-Methyl -4-piperidinol hydrochloride;
Downtream information
4-[(9-Cyclopentyl-7, 7-difluoro-5-methyl-6-oxo-6, 7, 8, 9-tetrahydro- 5H-pyrimido[4, 5-b][1, 4] diazepin-2-yl) amino] -3-methoxy-N-(1-methyl -4-piperidinyl) benzamide; 3-methoxy-N-(1-methylpiperidin-4-yl) -4-nitrobenzamide; 2-amino-4-methoxy-N-(1-methylpiperidin-4-yl) pyrimidine-5-carboxamide; 4-[[(7R) -8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl] amino] -3-methoxy-N-(1-methylpiperidin-4-yl) benzamide; 1-benzyl-N-(1-methylpiperidin-4-yl) benzimidazol-2-amine; 4-Amino-1-methylpiperidine hydrochloride; 4-Amino-1-methylpiperidine;
